Fenticonazole

Fenticonazole

Systematic (IUPAC) name
1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	prescription
Routes of administration	ovule, spray, cream
Identifiers
CAS Number	72479-26-6 Y
ATC code	D01AC12 (WHO) G01AF12
PubChem	CID: 51755
ChemSpider	46840 N
UNII	QG05NRB077 Y
KEGG	D02582 Y
ChEBI	CHEBI:82863 N
Chemical data
Formula	C24H20Cl2N2OS
Molecular mass	455.4 g/mol
SMILES c1ccc(cc1)Sc2ccc(cc2)COC(Cn3ccnc3)c4ccc(cc4Cl)Cl
InChI InChI=1S/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2 N Key:ZCJYUTQZBAIHBS-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Fenticonazole is an azole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.

Uses and administration

A 200-mg pessary is inserted into the vagina at bedtime for 3 nights or a 600-mg pessary is inserted once only at bedtime. Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.

Adverse effects

Burning and itching have been reported after the application of fenticonazole nitrate.

Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.

References

• The Merck Index, 12th Edition. 4047