23S ribosomal RNA
| Pseudoknot of the domain G(G12) of 23S ribosomal RNA | |
|---|---|
| 220px | |
| Predicted secondary structure and sequence conservation of PK-G12rRNA | |
| Identifiers | |
| Symbol | PK-G12rRNA |
| Rfam | RF01118 |
| Other data | |
| RNA type | Gene; rRNA |
| Domain(s) | Bacteria |
| SO | 0001263 |
The 23S rRNA is a 2904 nt long (in E. coli) component of the large subunit (50S) of the bacterial ribosome. The ribosomal peptidyl transferase activity resides in domain V of this rRNA, and this domain is the most common binding site for antibiotics that inhibit translation. A well-known member of this antibiotic class, chloramphenicol, acts by inhibiting peptide bond formation, with recent 3D-structural studies showing two different binding sites depending on the species of ribosome. Linezolid and quinupristin-dalfopristin also bind to the 23S rRNA, and cross-resistance has been demonstrated between these antibiotics.[citation needed]
See also
References
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<references />, or <references group="..." />External links
- Page for 23S_ribosomal_RNA at Rfam
- Pseudobase entry for pseudoknot of the 23S ribosomal RNA (PKB00148)
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