ADAM18

ADAM metallopeptidase domain 18
Identifiers
Symbols	ADAM18 ; ADAM27; tMDCIII
External IDs	MGI: 105986 HomoloGene: 74941 GeneCards: ADAM18 Gene
Gene ontology Molecular function • metalloendopeptidase activity • metallopeptidase activity • zinc ion binding Cellular component • membrane • integral component of membrane Biological process • proteolysis • multicellular organismal development • spermatogenesis • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ADAM18 207597 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8749	13524
Ensembl	ENSG00000168619	ENSMUSG00000031552
UniProt	Q9Y3Q7	Q9R157
RefSeq (mRNA)	NM_001190956	NM_010084
RefSeq (protein)	NP_001177885	NP_034214
Location (UCSC)	Chr 8: 39.58 – 39.73 Mb	Chr 8: 24.6 – 24.67 Mb
PubMed search	[1]	[2]

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.957