ARMET

Mesencephalic astrocyte-derived neurotrophic factor
250px Rendering based on PDB 2KVD.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KVD, 2KVE, 2W51
Identifiers
Symbols	MANF ; ARMET; ARP
External IDs	OMIM: 601916 MGI: 1922090 HomoloGene: 4383 GeneCards: MANF Gene
Gene ontology Molecular function • growth factor activity • poly(A) RNA binding Cellular component • extracellular region • nucleus Biological process • response to unfolded protein • biological_process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ARMET 202655 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7873	74840
Ensembl	ENSG00000145050	ENSMUSG00000032575
UniProt	P55145	Q3TMX5
RefSeq (mRNA)	NM_006010	NM_029103
RefSeq (protein)	NP_006001	NP_083379
Location (UCSC)	Chr 3: 51.39 – 51.39 Mb	Chr 9: 106.84 – 106.89 Mb
PubMed search	[1]	[2]

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein that in humans is encoded by the MANF gene.

This gene encodes a highly conserved protein whose function is known. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon.