ATP10A

ATPase, class V, type 10A
Identifiers
Symbols	ATP10A ; ATP10C; ATPVA; ATPVC
External IDs	OMIM: 605855 MGI: 1330809 HomoloGene: 56461 GeneCards: ATP10A Gene
EC number	3.6.3.1
Gene ontology Molecular function • magnesium ion binding • phospholipid-translocating ATPase activity • protein binding • ATP binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • integral component of membrane Biological process • intracellular protein transport • metabolic process • regulation of cell shape • ion transmembrane transport • phospholipid translocation • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ATP10A 214255 at tn.png
File:PBB GE ATP10A 214256 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57194	11982
Ensembl	ENSG00000206190	ENSMUSG00000025324
UniProt	O60312	O54827
RefSeq (mRNA)	NM_024490	NM_009728
RefSeq (protein)	NP_077816	NP_033858
Location (UCSC)	Chr 15: 25.68 – 25.87 Mb	Chr 7: 58.66 – 58.83 Mb
PubMed search	[1]	[2]

Probable phospholipid-transporting ATPase VA also known as ATPase class V type 10A (ATP10A) or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene.

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'.

See also

• Haloacid dehydrogenase superfamily