Alpha 1-antichymotrypsin
<templatestyles src="Module:Infobox/styles.css"></templatestyles>
Alpha 1-antichymotrypsin (α1AC)[1] is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene.
Contents
Function
Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.[2]
This protein is produced in the liver, and is an acute phase protein that is induced during inflammation.
Clinical significance
Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.[3]
Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.[2]
Interactions
Alpha 1-antichymotrypsin has been shown to interact with DNAJC1.[4]
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references> tag; parameter "group" is allowed only.
<references />, or <references group="..." />Further reading
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
External links
- The MEROPS online database for peptidases and their inhibitors: I04.002
- Alpha 1-antichymotrypsin at the US National Library of Medicine Medical Subject Headings (MeSH)
|
PDB gallery
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
||||||||||||
<templatestyles src="Asbox/styles.css"></templatestyles>
 |
This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it. |
