BIIE-0246

BIIE-0246

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Systematic (IUPAC) name
N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[([2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino)carbonyl]butyl]-1-(2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl)cyclopentaneacetamide
Identifiers
CAS Number	246146-55-4 Y
PubChem	CID: 9811493
IUPHAR/BPS	1547
ChemSpider	7987248 N
Synonyms	BIIE-0246
Chemical data
Formula	C49H57N11O6
Molecular mass	896.045 g/mol
SMILES O=C3N(c1ccccc1)N(c2ccccc2)C(=O)N3CCNC(=O)[C@@H](NC(=O)CC4(CCCC4)CC(=O)N8CCN(C7c5c(cccc5)NC(=O)c6ccccc67)CC8)CCC/N=C(\N)N
InChI InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m0/s1 N Key:RSJAXPUYVJKAAA-JPGJPTAESA-N N
NY (what is this?)  (verify)

BIIE-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y₂. It was one of the first non-peptide Y₂-selective antagonists developed, and remains among the most widely used tools for studying this receptor. It has been used to demonstrate a role for the Y₂ subtype as a presynaptic autoreceptor limiting further neuropeptide Y release, as well as modulating dopamine and acetylcholine release. It has also been shown to produce several behavioural effects in animals, including reducing alcohol consumption in addicted rats and anxiolytic effects, although while selective Y₂ agonists are expected to be useful as anorectics, BIIE-0246 did not appear to increase appetite when administered alone.

References

1. REDIRECT Template:Peptide receptor modulators