Betz cell

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Betz cell
GolgiStainedPyramidalCell.jpg
A human neocortical pyramidal neuron such as a Betz Cell stained via Golgi technique.
Details
Location Layer V of Cortex in primary motor cortex
Morphology Multipolar Pyramidal -- some of the longest axons in the body.
Function excitatory projection neuron to spinal cord
Neurotransmitter Glutamate
Presynaptic connections Superficial cortical layers, premotor cortex
Postsynaptic connections Ventral horn of the spinal cord
Identifiers
NeuroLex ID Betz Cell
TA Lua error in Module:Wikidata at line 744: attempt to index field 'wikibase' (a nil value).
TH {{#property:P1694}}
TE {{#property:P1693}}
FMA {{#property:P1402}}
Anatomical terminology
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]

Betz cells (also known as pyramidal cells of Betz) are giant pyramidal cells (neurons) located within the fifth layer of the grey matter in the primary motor cortex. They are named after Ukrainian scientist Vladimir Betz, who described them in his work published in 1874.[1] These neurons are the largest in the central nervous system, sometimes reaching 100 μm in diameter.[2][3] Betz cells are upper motor neurons that send their axons down to the spinal cord via the corticospinal tract, where in humans they synapse directly with anterior horn cells, which in turn synapse directly with their target muscles. While Betz cells have one apical dendrite typical of pyramidal neurons, they have more primary dendritic shafts, which can branch out at almost any point from the soma (cell body).[4] These perisomatic (around the cell body) and basal dendrites project into all cortical layers, but most of their horizontal branches/arbors populate layers V and VI, some reaching down into the white matter.[5] According to one study, Betz cells represent about 10% of the total pyramidal cell population in layer Vb of the human primary motor cortex.[6]

Notes

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External links

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  1. Betz W. (1874) Anatomischer Nachweis zweier Gehirncentra. Centralblatt für die medizinischen Wissenschaften. 12:578-580, 595-599.
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  3. Nolte, J. The Human Brain, 5th ed. Mosby: Missouri; 2002, p.527. ISBN 0-323-01320-1
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