CCL22

Chemokine (C-C motif) ligand 22
Identifiers
Symbols	CCL22 ; A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1
External IDs	OMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCards: CCL22 Gene
Gene ontology Molecular function • chemokine activity • CCR chemokine receptor binding Cellular component • extracellular region • extracellular space Biological process • monocyte chemotaxis • chemotaxis • inflammatory response • immune response • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • response to virus • neutrophil chemotaxis • positive regulation of GTPase activity • lymphocyte chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CCL22 207861 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6367	20299
Ensembl	ENSG00000102962	ENSMUSG00000031779
UniProt	O00626	O88430
RefSeq (mRNA)	NM_002990	NM_009137
RefSeq (protein)	NP_002981	NP_033163
Location (UCSC)	Chr 16: 57.36 – 57.37 Mb	Chr 8: 94.75 – 94.75 Mb
PubMed search	[1]	[2]

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4. The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.