CD180

CD180 molecule
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3B2D
Identifiers
Symbols	CD180 ; LY64; Ly78; RP105
External IDs	OMIM: 602226 MGI: 1194924 HomoloGene: 4077 GeneCards: CD180 Gene
Gene ontology Molecular function • receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • B cell proliferation involved in immune response • inflammatory response • positive regulation of lipopolysaccharide-mediated signaling pathway • innate immune response • cellular response to lipopolysaccharide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4064	17079
Ensembl	ENSG00000134061	ENSMUSG00000021624
UniProt	Q99467	Q62192
RefSeq (mRNA)	NM_005582	NM_008533
RefSeq (protein)	NP_005573	NP_032559
Location (UCSC)	Chr 5: 67.18 – 67.2 Mb	Chr 13: 102.69 – 102.74 Mb
PubMed search	[1]	[2]

CD180 antigen is a protein that in humans is encoded by the CD180 gene.

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.

Further reading

• [3]