CENTD1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
250px PDB rendering based on 1x40.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X40, 2COD
Identifiers
Symbols	ARAP2 ; CENTD1; PARX
External IDs	OMIM: 606645 MGI: 2684416 HomoloGene: 9064 GeneCards: ARAP2 Gene
Gene ontology Molecular function • GTPase activator activity • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding Cellular component • cytosol Biological process • small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CENTD1 213618 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	116984	212285
Ensembl	ENSG00000047365	ENSMUSG00000037999
UniProt	Q8WZ64	E9QP44
RefSeq (mRNA)	NM_015230	NM_178407
RefSeq (protein)	NP_056045	NP_848494
Location (UCSC)	Chr 4: 35.95 – 36.24 Mb	Chr 5: 62.6 – 62.77 Mb
PubMed search	[1]	[2]

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.