CENTD3

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KG5, 2LNW
Identifiers
Symbols	ARAP3 ; CENTD3; DRAG1
External IDs	OMIM: 606647 MGI: 2147274 HomoloGene: 11199 GeneCards: ARAP3 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • metal ion binding Cellular component • ruffle • cytoplasm • cytosol • cytoskeleton • plasma membrane • lamellipodium Biological process • cytoskeleton organization • small GTPase mediated signal transduction • regulation of cell shape • vesicle-mediated transport • negative regulation of cell migration • negative regulation of Rac protein signal transduction • negative regulation of Rho protein signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CENTD3 218950 at tn.png
File:PBB GE CENTD3 gnf1h01471 at tn.png
File:PBB GE CENTD3 gnf1h07750 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64411	106952
Ensembl	ENSG00000120318	ENSMUSG00000024451
UniProt	Q8WWN8	Q8R5G7
RefSeq (mRNA)	NM_022481	NM_001205336
RefSeq (protein)	NP_071926	NP_001192265
Location (UCSC)	Chr 5: 141.65 – 141.68 Mb	Chr 18: 37.97 – 38 Mb
PubMed search	[1]	[2]

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.