DOK1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.[1][2][3]
Function
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.[4]
Interactions
DOK1 has been shown to interact with:
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References
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Further reading
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