EIF1AX
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.[1][2][3] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.[3]
Function
eIF1A is a small proteins (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.[4]
Clinical significance
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[5]
Interactions
EIF1AX has been shown to interact with IPO13.[6]
References
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