Ebselen

Ebselen

Skeletal formula of ebselen
Ball-and-stick model of the ebselen molecule
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Names
IUPAC name 2-Phenyl-1,2-benzoselenazol-3-one
Identifiers
CAS Number	60940-34-3 Y
ChEBI	CHEBI:77543 N
ChEMBL	ChEMBL51085 Y
ChemSpider	3082 Y
Jmol 3D model	Interactive image Interactive image
PubChem	3194
UNII	40X2P7DPGH Y
InChI InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H Y Key: DYEFUKCXAQOFHX-UHFFFAOYSA-N Y InChI=1/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H Key: DYEFUKCXAQOFHX-UHFFFAOYAZ
SMILES C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2 O=C1c3ccccc3[Se]N1c2ccccc2
Properties
Chemical formula	C13H9NOSe
Molar mass	274.17666
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Ebselen (also called PZ 51, DR3305, and SPI-1005), is a synthetic organoselenium drug molecule with anti-inflammatory, anti-oxidant and cytoprotective activity. It acts as a mimic of glutathione peroxidase and can also react with peroxynitrite. It is being investigated as a possible treatment for reperfusion injury and stroke, hearing loss and tinnitus, and bipolar disorder.

Additionally, ebselen may be effective against Clostridium difficile infections.

Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides. Several ebselen analogues have been shown to scavenge hydrogen peroxide in the presence of thiols.