FG-7142
From Infogalactic: the planetary knowledge core
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Names | |
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IUPAC name
N-methyl-9H-pyrido[5,4-b]indole-3-carboxamide
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Identifiers | |
78538-74-6 ![]() |
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ChemSpider | 4222 |
Jmol 3D model | Interactive image |
MeSH | C526324 |
PubChem | 4375 |
UNII | 60PO70N1BP |
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Properties | |
C13H11N3O | |
Molar mass | 225.24594 |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
FG-7142 (ZK-31906) is a drug which acts as a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor.[1] It has anorectic,[2] anxiogenic and pro-convulsant effects.[3] It also increases release of acetylcholine and noradrenaline,[4] and improves memory retention in animal studies.[5]
References
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Cottone P, Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology. 2007 May;32(5):1069-81. PMID 17077811
- ↑ Evans AK, Lowry CA. Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects. CNS Drug Reviews. 2007 Winter;13(4):475-501. PMID 18078430
- ↑ Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R. Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat. Neuroscience. 2006 Sep 1;141(3):1481-8. PMID 16781820
- ↑ McNally GP, Augustyn KA, Richardson R. GABA(A) receptors determine the temporal dynamics of memory retention. Learning and Memory. 2008 Feb 19;15(3):106-11. PMID 18285469
Categories:
- Pages with reference errors
- Articles without EBI source
- Articles without KEGG source
- Pages using collapsible list with both background and text-align in titlestyle
- Chemical articles using a fixed chemical formula
- Anxiogenics
- Beta-Carbolines
- Convulsants
- GABAA receptor negative allosteric modulators
- Nootropics
- Carboxamides
- Biochemistry stubs