GAS6
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
Function
Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.[1]
Interactions
Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.[2][3]
The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum.
References
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