GRB14
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[1][2]
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[2]
Interactions
GRB14 has been shown to interact with Epidermal growth factor receptor,[3] Fibroblast growth factor receptor 1[4] and TNKS2.[5]
References
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This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |
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