Gabriella Campadelli-Fiume
| Gabriella Campadelli-Fiume | |
|---|---|
| Residence | Italy |
| Fields | Microbiology, Virology |
| Institutions | University of Bologna |
| Education | Doctorate of Science, University of Bologna |
| Known for | Discovered triggers of receptor-bound gD activity
Discovered that HSV utilizes gH/gL receptors, αvβ6- and αvβ8-intergins Discovered gD receptor, nectin1 to be HSV's receptor |
| Notable awards | Accademia Nazionale dei Lincei
Pasteur Institute, Athens Fellowship in the American Academy of Microbiology |
Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion[disambiguation needed] and viral entry.[1] She is a retired professor of virology from the University of Bologna, located in Italy.[1]
Contents
Education & Research
Gabriella Camapadelli-Fiume completed her Doctorate of Science (Sc.D) at the University of Bologna, Italy.[2] Her specialization in virology was completed at the University of Bologna, as well.[2] Campadelli-Fiume primarily researches Herpes Simplex Virus (HSV), particularly how HSV enters, assembles, and exits the cell during an active infection.[2] In addition, she is interested in how HSV is induced to enter the exocytic pathway.[2]
Primary Focus
- HSV entry into the cell [2]
- Viral assembly in cell [2]
- HSV exit out of the cell [2]
- Viral induced alteration of exocytic pathway [2]
Herpes Simplex Virus
Herpes Simplex Virus (HSV,herpes) consists of two types:
- Herpes simplex virus 1 (HSV-1)
- *Transmitted by oral contact, causes orolabial herpes (cold sores) and genital herpes [3]
- *HSV-1 is the most common infection through the world. It is a lifelong infection with no cure. However, treatment is available to minimize its symptoms
- Herpes simplex virus 2 (HSV-2)
- *Sexually transmitted infection, can also cause genital herpes. HSV-2 has no cure, as well. It is a lifelong disease [3]
- *Increased risk of acquiring HIV with HSV-2 [3]
- Herpesviruses
| Family | Herpesvirdae |
| Baltimore Classification | Group I |
| Genus Simplexvirus | Human Herpes simples virus type 1 |
| Genus Subfamily | Alphaherpesvirinae |
Major Discoveries
Campadelli-Fiume's discovery of nectin as the receptor for Herpes Simplex Virus (HSV), is one of her greatest accomplishments. Through her research, she also discovered the triggering activity of receptor- bound gD. In addition to these major discoveries, she uncovered the identity of the gF profusion domain, which provided the first evidence that retargeted HSVs exert anti-tumor activity.[4]
Additional Contributions to Virology
Gabriella Campadelli-Fiume took part in a study published in the Journal of Virology published on August 5, 2009.[5] The purpose of their research was to understand which glycoproteins were involved in the herpes simplex entry and fusion.[5] Their findings indicated that the gD, gB, and gH/gL glycoproteins permit the herpes virus to enter the cell.[5] Their research indicated that gD is not required for the interactions between the glycoproteins gB and gH/gL.[5] Rather, their interactions are made possible due to the multiple sites carried by gB.[5] The multiple sites of gB can be found in the pleckstrin-domain that carries the bipartite fusion loop, and interaction with gH/gL can take place successfully without gD.[5]
A Woman of Influence
Women have made significant progress towards equality within scientific fields of work. However, as efforts to increase women's participation in science fields, inequality exists. Furthermore, an underrepresented group of women remain in these fields.[6] Campadelli-Fiume is an influential woman who continues to bridge the gender gap within the scientific community. Her achievements throughout her career have earned substantial amounts of attention and credible recognition globally. As the author of an overall encyclopedic of basic virology and clinical manifestations, Human Herpesviruses,[7] her work has been included in the University of Pennsylvania’s 2007 Celebration of Women Writers.[8] She has gained recent attention for applaudable women in science by the International Society of Antiviral Research (ISAR) that has featured her as a prominent woman scientist.[9] The American Academy of Microbiology awarded recognition of her scientific achievement and her contributions to advanced microbiology.[10] Campadelli’s profound research, leadership principles, scientific achievements, and passion for virology, continue to convey a powerful impression to those within the scientific community. Her influence as a female scientist plays an important role to increasing the status of women in research.
Leadership
Gabriella Campadelli-Fiumme is an active member and leader in the scientific community.
Awards
- Accademia Nazionale dei Lincei ‘’2002’'[2]
- Pasteur Institute, Athens ‘’1997’'[2]
- Fellowship in the American Academy of Microbiology[10]
Editorial Activity
- (2005–Present) Serves as an editorial board member for the Journal of Virology[11]
- (2013–Present) Serves as an editorial board member for the Federation of European Microbiological Societies (FEMS) of Pathogens and Disease[11]
- Serves on the International Advisory Board for The Lancet Journal[11]
Scientific Society & Academy Founder
- European Society for Virology Founding Member & Executive Board Member[11]
- European Academy of Microbiology Founding Member[11]
- Italian Society of Virology Founding Member[11]
Committee Service
- Member of Health Research Committee from 2000-2006'[11]
Major Publications
Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus
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Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-kB
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AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts
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Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain
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Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2
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Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain
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Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies
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A Herpes Simplex Virus Recombinant That Exhibits a Single-Chain Antibody to HER2/neu Enters Cells through the Mammary Tumor Receptor, Independently of the gD Receptors
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Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
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Hydrophobic α-Helices 1 and 2 of Herpes Simplex Virus gH Interact with Lipids, and Their Mimetic Peptides Enhance Virus Infection and Fusion
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The Egress of Herpesviruses from Cells: the Unanswered Questions
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The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane α-Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family
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Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression
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Entry of Herpes Simplex Virus Mediated by Chimeric Forms of Nectin1 Retargeted to Endosomes or to Lipid Rafts Occurs through Acidic Endosomes
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The Herpes Simplex Virus JMP Mutant Enters Receptor-Negative J Cells through a Novel Pathway Independent of the Known Receptors nectin1, HveA, and nectin2
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References
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- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Lua error in package.lua at line 80: module 'strict' not found.
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