HIST1H2AI

Histone cluster 1, H2ai
250px PDB rendering based on 1aoi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4QYL
Identifiers
Symbols	HIST1H2AI ; H2A/c; H2AFC
External IDs	OMIM: 602787 HomoloGene: 134476 GeneCards: HIST1H2AI Gene
Gene ontology Molecular function • DNA binding • protein binding • enzyme binding • protein heterodimerization activity Cellular component • nucleosome • nucleus • extracellular exosome Biological process • biological_process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8329	319168
Ensembl	ENSG00000196747	ENSMUSG00000061615
UniProt	P0C0S8	Q8CGP6
RefSeq (mRNA)	NM_003509	NM_175659
RefSeq (protein)	NP_003500	NP_783590
Location (UCSC)	Chr 6: 27.81 – 27.81 Mb	Chr 13: 21.72 – 21.72 Mb
PubMed search	[1]	[2]

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.