Hsp20
| Hsp20/alpha crystallin family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | HSP20 | ||||||||
| Pfam | PF00011 | ||||||||
| InterPro | IPR002068 | ||||||||
| PROSITE | PDOC00791 | ||||||||
| SCOP | 1shs | ||||||||
| SUPERFAMILY | 1shs | ||||||||
| CDD | cd06464 | ||||||||
|
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Heat shock protein Hsp20 is a family of heat shock proteins.
Prokaryotic and eukaryotic organisms respond to heat shock or other environmental stress by inducing the synthesis of proteins collectively known as heat-shock proteins (hsp).[1] Amongst them is a family of proteins with an average molecular weight of 20 kDa, known as the hsp20 proteins.[2] These seem to act as protein chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterised by the presence of a conserved C-terminal domain, alpha-crystallin domain, of about 100 residues. Recently, small heat shock proteins (sHSPs) were found in marine viruses (cyanophages).[3]
Human proteins containing this domain
CRYAA; CRYAB; HSPB1; HSPB2; HSPB3; HSPB6; HSPB7; HSPB8; HSPB9;
References
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