Interleukin 31
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| Interleukin 31 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IL31 ; IL-31 | ||||||||||||
| External IDs | OMIM: 609509 HomoloGene: 88541 GeneCards: IL31 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 386653 | n/a | |||||||||||
| Ensembl | ENSG00000204671 | n/a | |||||||||||
| UniProt | Q6EBC2 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001014336 | n/a | |||||||||||
| RefSeq (protein) | NP_001014358 | n/a | |||||||||||
| Location (UCSC) | Chr 12: 122.17 – 122.17 Mb |
n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
Interleukin-31 also known as IL-31 is a protein that in humans is encoded by the IL31 gene.[1][2]
Function
IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells.[1]
Clinical significance
IL-31 is believed to play a role in inflammation of the skin.[2]
References
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