IRS2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.[1]
Function
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.[2]
Mice lacking IRS2 have a diabetic phenotype[3] as well as a 40% reduction in brain mass.[4]
Interactions
IRS2 has been shown to interact with:
References
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Further reading
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This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it. |
