Joachim Jose
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Joachim Jose is professor for pharmaceutical and medical chemistry at the University of Münster, and focuses primarily on the research of bacterial development of drugs and biocatalysts by surface display.
Curriculum Vitae
Joachim Jose is a German chemist. He studied biology at the Saarland University in Saarbrücken and received his PhD in 1994. From 1994 - 1997, he was a post-doctoral research fellow at the Max Planck Institute for Biology in Tübingen. He was an Assistant Professor (C1) at the Institute of Pharmaceutical and Medicinal Chemistry at the University Saarbrücken from 1998 - 2004 and finished his habilitation in 2003 by a thesis on the "Evolutive design of Drugs and biocatalysts by bacterial surface display", followed by the appointment as a "Privatdozent". In 2004, he accepted an offer of the Heinrich-Heine-University Düesseldorf for an Associate Professorship (C3) in Bioanalytics at The Institute of Pharmaceutical and Medicinal Chemistry where he was appointed director of the institute in 2008. In 2010, he accepted an offer of the Westfälische Wilhelms-University for a full Professorship (W3). Since March 2011, he is working with his group in Münster, is head of the institute and holds a chair in Pharmaceutical and Medicinal Chemistry
Scientific Awards
- 1998 Innovation Award
- 2004 Research Award of the SaarLB
- 2009 Corresponding Member of the French National Academy of Pharmacy
Key Publications
(1) Kranen E, Steffan N, Maas RM, Li SM, Jose J (2011) Development of a whole cell biocatalyst for the efficient prenylation of indole derivatives by Autodisplay of the aromatic prenyltransferase FgaPT2, ChemCatChem, 3:1200-1207.
(2) Kaeßler A, Olgen S, Jose J (2011) Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors. Europ J Pharm Sci, 42: 138-147.
(3) Gratz A, Götz, C, Jose J (2010) Capillary electrophoresis based method for human protein kinase CK2 activity measurement and inhibitor screening. Electrophoresis, 31:634-640.
(4) Jose J, Park M, Pyun JC (2010) E. coli outer membrane with autodisplayed Z-domain as a molecular recognition layer of SPR biosensor. Biosens Bioelectron, 25:1225-1228.
(5) Jose J, Bernhardt R, Hannemann F (2001) Functional display of active bovine adrenodoxin on the surface of E. coli by chemical incorporation of the [2Fe-2S] cluster. ChemBioChem, 2:695-701.
(6) Hartmann RW, Hector M, Haidar S, Ehmer PB, Reichert W, Jose J (2000) Synthesis and Evaluation of Novel Steroidal Oximes Inhibitors of P450 17 (17α-Hydroxylase/C17-20-Lyase) and 5α-Reductase Type 1 and 2. J Med Chem, 43:4266-4277.
(7) Maurer J, Jose J, Meyer TF (1997) Autodisplay: One-component-system for efficient surface display and release of soluble recombinant proteins from Escherichia coli. J Bacteriol, 179:794-804.
(8) Jose J, Jähnig F, Meyer TF (1995) Common structural features of IgA1-protease-like outer membrane protein autotransporters. Mol Microbiol 18: 380-382.
(9) Jose J, Meyer TF (2007) The autodisplay story – from discovery to biotechnical and biomedical applications. Microbiol Mol Biol R, 71:600-619.
