MHC class I polypeptide-related sequence A
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus.[1] MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.[1] However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do.[2] MICA rather functions as a stress-induced ligand for NKG2D receptor.[3] For example, the heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element.[2] MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated.[3]
See also
References
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