MK-212

MK-212

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Names
IUPAC name 2-Chloro-6-(1-piperazinyl)pyrazine
Other names CPP
Identifiers
CAS Number	64022-27-1 Y
ChemSpider	97104
IUPHAR/BPS	165
Jmol 3D model	Interactive image
PubChem	107992
InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2 Key: CJAWPFJGFFNXQI-UHFFFAOYSA-N InChI=1/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2 Key: CJAWPFJGFFNXQI-UHFFFAOYAX
SMILES Clc1nc(cnc1)N2CCNCC2
Properties
Chemical formula	C8H11ClN4
Molar mass	198.65 g·mol−1
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

MK-212 (CPP or 6-chloro-2-(l-piperazinyl)pyrazine) is a serotonin agonist. It promotes the secretion of serum prolactin and cortisol in humans.

Experiment

In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects. The result correlated very well to binding of indolealkylamine receptors, such as the serotonin and tryptamine receptors, which shows four characteristics. Namely, increased frequency of muscle twitching, increased twitching of the head, "an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.