MKL1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.[1][2][3][4]
Function
The protein encoded by this gene interacts with the transcription factor serum response factor,[5] a key regulator of smooth muscle cell differentiation. It is closely related to MKL2 and myocardin.[6] The encoded protein can shuttle between the cytoplasm and the nucleus, and may help this way transduce signals from the cytoskeleton to the nucleus.[7]
Clinical significance
This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.[4]
References
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This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it. |
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