MS4A2

Membrane-spanning 4-domains, subfamily A, member 2
Identifiers
Symbols	MS4A2 ; APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1
External IDs	OMIM: 147138 MGI: 95495 HomoloGene: 112 GeneCards: MS4A2 Gene
Gene ontology Molecular function • IgE receptor activity • IgE binding • protein kinase binding • SH2 domain binding • phosphoprotein binding Cellular component • endosome • plasma membrane • integral component of plasma membrane • external side of plasma membrane • Fc-epsilon receptor I complex • membrane raft Biological process • inflammatory response • immune response • activation of phospholipase C activity • protein kinase C-activating G-protein coupled receptor signaling pathway • Fc-epsilon receptor signaling pathway • positive regulation of mast cell degranulation • innate immune response • cytokine secretion • regulation of release of sequestered calcium ion into cytosol Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MS4A2 207497 s at tn.png
File:PBB GE MS4A2 207496 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2206	14126
Ensembl	ENSG00000149534	ENSMUSG00000024680
UniProt	Q01362	P20490
RefSeq (mRNA)	NM_000139	NM_001276328
RefSeq (protein)	NP_000130	NP_001263257
Location (UCSC)	Chr 11: 60.09 – 60.1 Mb	Chr 19: 11.62 – 11.62 Mb
PubMed search	[1]	[2]

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.

See also

• FcεRI

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.