PAS domain
From Infogalactic: the planetary knowledge core
| PAS fold | |||||||||
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| File:FixL 1y28.png
Crystallographic structure of the PAS domain of the bacterial oxygen sensor protein fixL.[1] The protein is depicted as a rainbow colored cartoon (N-terminus = blue, C-terminus = red while the heme ligand is shown as sticks (carbon = white, nitrogen = blue, oxygen = red, iron = orange).
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| Identifiers | |||||||||
| Symbol | PAS | ||||||||
| Pfam | PF00989 | ||||||||
| InterPro | IPR013767 | ||||||||
| SMART | PAS | ||||||||
| PROSITE | PDOC50112 | ||||||||
| SCOP | 2phy | ||||||||
| SUPERFAMILY | 2phy | ||||||||
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The PAS domain is a protein domain contained in many signaling proteins where it functions as a signal sensor.[2][3] PAS domains are found in a large number of organisms from bacteria to humans. The PAS domain was named after the three proteins in which it was first discovered:
- Per – period circadian protein
- Arnt – aryl hydrocarbon receptor nuclear translocator protein
- Sim – single-minded protein
Many PAS-domain proteins detect their signal by way of an associated cofactor such as heme.[4] Proteins that contain a PAS domain include Hypoxia-inducible factors.
References
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