RAG1

Recombination activating gene 1
Identifiers
Symbols	RAG1 ; RAG-1; RNF74
External IDs	OMIM: 179615 HomoloGene: 387 GeneCards: RAG1 Gene
Gene ontology Molecular function • DNA binding • endonuclease activity • ubiquitin-protein transferase activity • protein binding • zinc ion binding • acid-amino acid ligase activity • histone binding • protein homodimerization activity • sequence-specific DNA binding • metal ion binding Cellular component • nucleus Biological process • adaptive immune response • pre-B cell allelic exclusion • DNA recombination • immune response • histone monoubiquitination • B cell differentiation • T cell differentiation in thymus • V(D)J recombination • T cell homeostasis • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of T cell differentiation • thymus development • protein autoubiquitination • negative regulation of thymocyte apoptotic process • nucleic acid phosphodiester bond hydrolysis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5896	19373
Ensembl	ENSG00000166349	ENSMUSG00000061311
UniProt	P15918	P15919
RefSeq (mRNA)	NM_000448	NM_009019
RefSeq (protein)	NP_000439	NP_033045
Location (UCSC)	Chr 11: 36.51 – 36.59 Mb	Chr 2: 101.64 – 101.65 Mb
PubMed search	[1]	[2]

Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.