RASA4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[1][2]
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
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<references />, or <references group="..." />Further reading
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External links
- RASA4 human gene location in the UCSC Genome Browser.
- RASA4 human gene details in the UCSC Genome Browser.
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