RGS10
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.[1][2]
Function
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.[2]
Interactions
RGS10 has been shown to interact with SAP18[3] and GNAI3.[1]
References
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