RGS17

Regulator of G-protein signaling 17
250px PDB rendering based on 1zv4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZV4
Identifiers
Symbols	RGS17 ; RGS-17; RGSZ2; hRGS17
External IDs	OMIM: 607191 MGI: 1927469 HomoloGene: 8242 GeneCards: RGS17 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding Cellular component • nucleus • cytoplasm • plasma membrane Biological process • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE RGS17 220334 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26575	56533
Ensembl	ENSG00000091844	ENSMUSG00000019775
UniProt	Q9UGC6	Q9QZB0
RefSeq (mRNA)	NM_012419	NM_001161822
RefSeq (protein)	NP_036551	NP_001155294
Location (UCSC)	Chr 6: 153 – 153.13 Mb	Chr 10: 5.83 – 5.92 Mb
PubMed search	[1]	[2]

Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Along with RGS4, RGS9 and RGS14, RGS17 plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs.

Clinical significance

RGS17 is a putative lung cancer susceptibility gene in the lung cancer associated locus on chromosome 6q in humans. RGS17 is overexpressed in lung and prostate cancers, induces cAMP production, CREB phosphorylation and CREB responsive gene expression[2]. Expression of RGS17 is required for maintenance of proliferation in lung tumor cell lines.