SR-142948

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SR-142948
240px
Systematic (IUPAC) name
2-([5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino)adamantane-2-carboxylic acid
Identifiers
CAS Number 184162-64-9
PubChem CID: 5311451
IUPHAR/BPS 1580
ChemSpider 4470937 YesY
Chemical data
Formula C39H51N5O6
Molecular mass 685.850 g/mol
  • O=C(O)C6(NC(=O)c2nn(c1c(cc(C(=O)N(CCCN(C)C)C)cc1)C(C)C)c(c2)c3c(OC)cccc3OC)C4CC5CC6CC(C4)C5
  • InChI=1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48) YesY
  • Key:LWULHXVBLMWCHO-UHFFFAOYSA-N YesY
  (verify)

SR-142948 is a drug used in scientific research which is a non-peptide antagonist selective for the neurotensin receptors, although not selective between subtypes.[1] It has been used to study the role of neurotensin in the regulation of dopamine receptor activity[2][3][4][5] and glutamate signalling in the brain,[6][7] and in animal studies SR-142948 blocked the effects of stimulant drugs,[8] including MDMA.[9]

References

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  1. REDIRECT Template:Peptide receptor modulators


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