STAP1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.[1][2][3]
Function
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.[3]
Interactions
STAP1 has been shown to interact with C19orf2.[4]
References
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