TACSTD2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),[1] is a protein that in humans is encoded by the TACSTD2 gene.[2][3][4]
This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.
Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.[4]
This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.
References
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This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |
- ↑ Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [1]
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