TLR5

Toll-like receptor 5
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1P95, 3J0A
Identifiers
Symbols	TLR5 ; MELIOS; SLE1; SLEB1; TIL3
External IDs	OMIM: 603031 MGI: 1858171 HomoloGene: 20698 GeneCards: TLR5 Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • interleukin-1 receptor binding Cellular component • plasma membrane • integral component of membrane Biological process • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • inflammatory response • male gonad development • positive regulation of interleukin-8 production • positive regulation of toll-like receptor signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 10 signaling pathway • defense response to bacterium • innate immune response • positive regulation of nitric oxide biosynthetic process • regulation of cytokine secretion • cellular response to lipopolysaccharide • cellular response to mechanical stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TLR5 210166 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7100	53791
Ensembl	ENSG00000187554	ENSMUSG00000079164
UniProt	O60602	Q9JLF7
RefSeq (mRNA)	NM_003268	NM_016928
RefSeq (protein)	NP_003259	NP_058624
Location (UCSC)	Chr 1: 223.11 – 223.14 Mb	Chr 1: 182.95 – 182.98 Mb
PubMed search	[1]	[2]

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll-like receptor (TLR) family.

Function

The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR5 is expressed on both immune and non-immune cells. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-κB and stimulates tumor necrosis factor-alpha production.

TLR5 recognizes flagellin, which is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5.

External links

• Toll-Like Receptor 5 at the US National Library of Medicine Medical Subject Headings (MeSH)