Talastine

Talastine
	File:Talastine.png
Systematic (IUPAC) name
	4-benzyl-2-[2-(dimethylamino)ethyl]phthalazin-1(2H)-one
Identifiers
CAS Number	16188-61-7
ATC code	R06AB07 (WHO)
PubChem	CID: 65624
ChemSpider	59065
UNII	49AB2PA48B
Chemical data
Formula	C19H21N3O
Molecular mass	307.39 g/mol
	SMILES O=C1c3ccccc3\C(=N/N1CCN(C)C)Cc2ccccc2 ;
	InChI InChI=1S/C19H21N3O/c1-21(2)12-13-22-19(23)17-11-7-6-10-16(17)18(20-22)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3 ; Key:LCAAMXMULMCKLJ-UHFFFAOYSA-N ;
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Talastine (trade name Ahanon) is an antihistamine.^[1]

Synthesis

The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with diethylaminoethyl chloride.^[2]

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↑ Engelbrecht et al., DE 1046625 ; eidem, U.S. Patent 3,017,411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben).