Template:PBB/2737

GLI family zinc finger 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4BLD
Identifiers
Symbols	GLI3 ; ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV
External IDs	OMIM: 165240 MGI: 95729 HomoloGene: 139 GeneCards: GLI3 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • beta-catenin binding • histone acetyltransferase binding • histone deacetylase binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • cilium • axoneme • mediator complex • nuclear speck • transcriptional repressor complex • primary cilium • ciliary tip • ciliary base Biological process • negative regulation of transcription from RNA polymerase II promoter • metanephros development • branching involved in ureteric bud morphogenesis • in utero embryonic development • positive regulation of neuroblast proliferation • transcription from RNA polymerase II promoter • smoothened signaling pathway • axon guidance • hindgut morphogenesis • heart development • negative regulation of cell proliferation • anterior/posterior pattern specification • proximal/distal pattern formation • protein processing • optic nerve morphogenesis • hippocampus development • smoothened signaling pathway involved in ventral spinal cord interneuron specification • smoothened signaling pathway involved in spinal cord motor neuron cell fate specification • forebrain dorsal/ventral pattern formation • cerebral cortex radial glia guided migration • forebrain radial glial cell differentiation • lateral ganglionic eminence cell proliferation • melanocyte differentiation • lung development • positive regulation of chondrocyte differentiation • T cell differentiation in thymus • limb morphogenesis • wound healing • positive regulation of protein import into nucleus • odontogenesis of dentin-containing tooth • embryonic digit morphogenesis • negative regulation of apoptotic process • nose morphogenesis • tongue development • response to estrogen • negative thymic T cell selection • negative regulation of neuron differentiation • positive regulation of osteoblast differentiation • negative regulation of smoothened signaling pathway • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of alpha-beta T cell differentiation • negative regulation of alpha-beta T cell differentiation • embryonic digestive tract morphogenesis • embryonic digestive tract development • developmental growth • camera-type eye morphogenesis • embryonic skeletal system morphogenesis • oligodendrocyte differentiation • palate development • frontal suture morphogenesis • lambdoid suture morphogenesis • sagittal suture morphogenesis • mammary gland specification • smoothened signaling pathway involved in dorsal/ventral neural tube patterning • artery development • anterior semicircular canal development • lateral semicircular canal development • cell differentiation involved in kidney development • thymocyte apoptotic process • negative regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE GLI3 205201 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2737	14634
Ensembl	ENSG00000106571	ENSMUSG00000021318
UniProt	P10071	Q61602
RefSeq (mRNA)	NM_000168	NM_008130
RefSeq (protein)	NP_000159	NP_032156
Location (UCSC)	Chr 7: 41.96 – 42.24 Mb	Chr 13: 15.46 – 15.73 Mb
PubMed search	[1]	[2]