Template:PBB/3552

Interleukin 1, alpha
PDB rendering based on 2ila.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ITA, 2ILA, 2KKI, 2L5X
Identifiers
Symbols	IL1A ; IL-1A; IL1; IL1-ALPHA; IL1F1
External IDs	OMIM: 147760 MGI: 96542 HomoloGene: 480 GeneCards: IL1A Gene
Gene ontology Molecular function • cytokine activity • interleukin-1 receptor binding • copper ion binding • protein binding Cellular component • extracellular region • extracellular space • cytosol Biological process • fever generation • connective tissue replacement involved in inflammatory response wound healing • inflammatory response to antigenic stimulus • apoptotic process • inflammatory response • cell proliferation • negative regulation of cell proliferation • positive regulation of vascular endothelial growth factor production • positive regulation of gene expression • cytokine-mediated signaling pathway • cellular response to heat • ectopic germ cell programmed cell death • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of interleukin-2 biosynthetic process • positive regulation of angiogenesis • positive regulation of mitotic nuclear division • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • response to copper ion • positive regulation of protein secretion • positive regulation of cytokine secretion • positive regulation of ERK1 and ERK2 cascade • extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE IL1A 210118 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3552	16175
Ensembl	ENSG00000115008	ENSMUSG00000027399
UniProt	P01583	P01582
RefSeq (mRNA)	NM_000575	NM_010554
RefSeq (protein)	NP_000566	NP_034684
Location (UCSC)	Chr 2: 112.77 – 112.78 Mb	Chr 2: 129.3 – 129.31 Mb
PubMed search	[1]	[2]