Template:PBB/5054

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
PAI-1 in complex with the SMB domain of Vitronectin PDB: 1OC0​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 4G8O, 4G8R, 4IC0, 9PAI
Identifiers
Symbols	SERPINE1 ; PAI; PAI-1; PAI1; PLANH1
External IDs	OMIM: 173360 MGI: 97608 HomoloGene: 68070 ChEMBL: 3475 GeneCards: SERPINE1 Gene
Gene ontology Molecular function • protease binding • serine-type endopeptidase inhibitor activity • receptor binding • protein binding Cellular component • extracellular region • extracellular space • plasma membrane • extracellular matrix • platelet alpha granule lumen • extracellular exosome Biological process • chronological cell aging • angiogenesis • platelet degranulation • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • blood coagulation • circadian rhythm • gene expression • regulation of receptor activity • negative regulation of plasminogen activation • negative regulation of endopeptidase activity • negative regulation of smooth muscle cell migration • platelet activation • positive regulation of blood coagulation • negative regulation of blood coagulation • extracellular matrix organization • negative regulation of cell migration • positive regulation of interleukin-8 production • negative regulation of cell adhesion mediated by integrin • positive regulation of leukotriene production involved in inflammatory response • fibrinolysis • positive regulation of angiogenesis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of receptor-mediated endocytosis • positive regulation of inflammatory response • defense response to Gram-negative bacterium • negative regulation of fibrinolysis • negative regulation of vascular wound healing • negative regulation of wound healing • cellular response to lipopolysaccharide • positive regulation of monocyte chemotaxis • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of smooth muscle cell-matrix adhesion • negative regulation of endothelial cell apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5054	18787
Ensembl	ENSG00000106366	ENSMUSG00000037411
UniProt	P05121	n/a
RefSeq (mRNA)	NM_000602	NM_008871
RefSeq (protein)	NP_000593	NP_032897
Location (UCSC)	Chr 7: 101.13 – 101.14 Mb	Chr 5: 137.06 – 137.07 Mb
PubMed search	[1]	[2]