Touton giant cell
Touton giant cells are a type of multinucleated giant cell seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthogranulomas. They are also found in dermatofibroma.[1]
History
Touton giant cells are named for Karl Touton, a German botanist and dermatologist.[2] Karl Touton first observed these cells in 1885 and named them "xanthelasmatic giant cells", a name which has since fallen out of favor.[3]
Appearance
Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. They contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei.[4][5] The cytoplasm surrounded by the nuclei has been described as both amphophilic and eosinophilic, while the cytoplasm near the periphery of the cell is pale and foamy in appearance.[6]
Causes
Touton giant cells are formed by the fusion of macrophage-derived foam cells. It has been suggested that cytokines such as interferon gamma, interleukin-3, and M-CSF may be involved in the production of Touton giant cells.[7][8]
References
<templatestyles src="Reflist/styles.css" />
Cite error: Invalid <references> tag; parameter "group" is allowed only.
<references />, or <references group="..." />External links
<templatestyles src="Asbox/styles.css"></templatestyles>
 |
This cell biology article is a stub. You can help Wikipedia by expanding it. |
<templatestyles src="Asbox/styles.css"></templatestyles>
 |
This immunology article is a stub. You can help Wikipedia by expanding it. |
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
