UGT1A9

UDP glucuronosyltransferase 1 family, polypeptide A9
Identifiers
Symbols	UGT1A9 ; HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I; UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I
External IDs	OMIM: 606434 MGI: 3576092 HomoloGene: 133281 ChEMBL: 1743319 GeneCards: UGT1A9 Gene
EC number	2.4.1.17
Gene ontology Molecular function • retinoic acid binding • enzyme inhibitor activity • glucuronosyltransferase activity • enzyme binding • protein homodimerization activity • protein heterodimerization activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of membrane • extracellular exosome Biological process • xenobiotic metabolic process • metabolic process • flavonoid biosynthetic process • drug metabolic process • cellular response to hormone stimulus • retinoic acid metabolic process • cellular lipid metabolic process • small molecule metabolic process • negative regulation of fatty acid metabolic process • flavone metabolic process • cellular glucuronidation • flavonoid glucuronidation • xenobiotic glucuronidation • negative regulation of glucuronosyltransferase activity • negative regulation of cellular glucuronidation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54600	394430
Ensembl	ENSG00000241119	ENSMUSG00000090165
UniProt	O60656	D3Z7G0
RefSeq (mRNA)	NM_021027	NM_201641
RefSeq (protein)	NP_066307	NP_964003
Location (UCSC)	Chr 2: 233.67 – 233.77 Mb	Chr 1: 88.06 – 88.22 Mb
PubMed search	[1]	[2]

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Irinotecan Pathway edit]]

File:IrinotecanPathway_WP229.png

Irinotecan Pathway edit

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.