UQCR11
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Ubiquinol-cytochrome c reductase, complex III subunit XI | |||||||||||||
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Identifiers | |||||||||||||
Symbols | UQCR11 ; 0710008D09Rik; QCR10; UQCR | ||||||||||||
External IDs | OMIM: 609711 HomoloGene: 4974 GeneCards: UQCR11 Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 10975 | 66594 | |||||||||||
Ensembl | ENSG00000127540 | ENSMUSG00000020163 | |||||||||||
UniProt | O14957 | Q9CPX8 | |||||||||||
RefSeq (mRNA) | NM_006830 | NM_025650 | |||||||||||
RefSeq (protein) | NP_006821 | NP_079926 | |||||||||||
Location (UCSC) | Chr 19: 1.6 – 1.61 Mb |
Chr 10: 80.4 – 80.41 Mb |
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PubMed search | [1] | [2] | |||||||||||
UQCR11 (ubiquinol-cytochrome c reductase, complex III subunit XI) is a protein that in humans is encoded by the UQCR11 gene.[1][2] UQCR11 is the smallest known component of Complex III in the mitochondrial respiratory chain.[2]
Structure
The UQCR11 gene, located on the p arm of chromosome 19 in position 13.3, is made up of 3 exons and is 8,329 base pairs in length.[2] The UQCR11 protein weighs 6.6 kDa and is composed of 56 amino acids.[3][4] This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which is also known as Complex III and is part of the mitochondrial respiratory chain.[2] In vertebrates, Complex III contains 11 subunits: 3 respiratory subunits, 2 core proteins and 6 low-molecular weight proteins.[5][6] Proteobacterial complexes may contain as few as three subunits.[7]
Function
The UQCR11 protein may function as a binding factor for the iron-sulfur protein in Complex III, which is ubiquitous in human cells.[2] Complex III catalyzes the chemical reaction
- QH2 + 2 ferricytochrome c
Q + 2 ferrocytochrome c + 2 H+
Thus, the two substrates of Complex III are dihydroquinone (QH2) and ferri- (Fe3+) cytochrome c, whereas its 3 products are quinone (Q), ferro- (Fe2+) cytochrome c, and H+. This complex belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with a cytochrome as acceptor. This enzyme participates in oxidative phosphorylation. It has four cofactors: cytochrome c1, cytochrome b-562, cytochrome b-566 and a 2-Iron ferredoxin of the Rieske type.
References
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.