AMP deaminase
<templatestyles src="Module:Infobox/styles.css"></templatestyles>
Adenosine monophosphate deaminase 1 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||
Symbols | AMPD1 ; MAD; MADA; MMDD | ||||||||||||
External IDs | OMIM: 102770 MGI: 88015 HomoloGene: 20 ChEMBL: 2869 GeneCards: AMPD1 Gene | ||||||||||||
EC number | 3.5.4.6 | ||||||||||||
|
|||||||||||||
RNA expression pattern | |||||||||||||
File:PBB GE AMPD1 206121 at tn.png | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 270 | 229665 | |||||||||||
Ensembl | ENSG00000116748 | ENSMUSG00000070385 | |||||||||||
UniProt | P23109 | Q3V1D3 | |||||||||||
RefSeq (mRNA) | NM_000036 | NM_001033303 | |||||||||||
RefSeq (protein) | NP_000027 | NP_001028475 | |||||||||||
Location (UCSC) | Chr 1: 114.67 – 114.7 Mb |
Chr 3: 103.07 – 103.1 Mb |
|||||||||||
PubMed search | [1] | [2] | |||||||||||
AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene.[1][2]
Adenosine monophosphate deaminase is an enzyme that converts adenosine monophosphate (AMP) to inosine monophosphate (IMP), freeing an ammonia molecule in the process.
Contents
Function
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythrocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.[2]
Function
It is a part of the metabolic process that converts sugar, fat, and protein into cellular energy.[citation needed]
In order to use energy, a cell converts one of the above fuels into adenosine triphosphate (ATP) via the mitochondria. Cellular processes, especially muscles, then convert the ATP into adenosine diphosphate (ADP), freeing the energy to do work.[citation needed]
A new research report shows that the widely-prescribed diabetes medication metformin works on AMP kinase by directly inhibiting AMP deaminase, thereby increasing cellular AMP.[3]
Regulation
It has been shown that in environments with high potassium concentrations, AMP-deaminase is regulated by ATP and ADP through a “Km-type” mechanism. In low potassium ion concentrations, a mixed “Km V-type” of the regulation is observed. [4]
Pathology
A deficiency is associated with myoadenylate deaminase deficiency.
-
adenosine monophosphate (AMP)
-
inosine monophosphate (IMP)
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 EntrezGene 270
- ↑ Lua error in package.lua at line 80: module 'strict' not found.[unreliable medical source?]
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
Further reading
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
- Lua error in package.lua at line 80: module 'strict' not found.
External links
- AMP Deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
<templatestyles src="Asbox/styles.css"></templatestyles>