DPYS

Dihydropyrimidinase
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VR2
Identifiers
Symbols	DPYS ; DHP; DHPase
External IDs	OMIM: 613326 MGI: 1928679 HomoloGene: 20359 ChEMBL: 2465 GeneCards: DPYS Gene
EC number	3.5.2.2
Gene ontology Molecular function • uracil binding • thymine binding • dihydropyrimidinase activity • zinc ion binding • amino acid binding • phosphoprotein binding Cellular component • cytosol • extracellular exosome Biological process • pyrimidine nucleobase metabolic process • pyrimidine nucleobase catabolic process • thymine catabolic process • uracil catabolic process • beta-alanine metabolic process • small molecule metabolic process • pyrimidine nucleoside catabolic process • protein homotetramerization • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE DPYS 206065 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1807	64705
Ensembl	ENSG00000147647	ENSMUSG00000022304
UniProt	Q14117	Q9EQF5
RefSeq (mRNA)	NM_001385	NM_001164466
RefSeq (protein)	NP_001376	NP_001157938
Location (UCSC)	Chr 8: 104.33 – 104.47 Mb	Chr 15: 39.77 – 39.86 Mb
PubMed search	[1]	[2]

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

File:FluoropyrimidineActivity_WP1601.png

Fluorouracil (5-FU) Activity edit