HLA-DR16
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major histocompatibility complex, class II, DR16
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| Haplotypes groups | DRA*01:DRB1*1601 DRA*01:DRB1*1602 |
| Structure (See HLA-DR) | |
| Identifiers |
alpha *0101
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| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers |
beta 1 *1601 *1602 *1604
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| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1601 |
| EBI-HLA | DRB1*1602 |
| EBI-HLA | DRB1*1604 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.
Alleles
| DRB1* | DR16 | DR2 | DR15 | Sample |
| allele | % | % | % | size (N) |
| 1601 | 41 | 29 | 19 | 703 |
| 1602 | 47 | 30 | 16 | 239 |
| 1604 | >50 | 1 |
Disease associations
DR16 is associated with Chaga's cardiomyopathy,[2] rheumatic heart disease,[3] coronary artery ectasia,[4] and chronic discoid lupus erythematosus.[5]
DRB1*1601 is associated with tuberculosis risk[6]
DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11]
Extended linkage
DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]
Genetic Linkage
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DR16 Haplotypes
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| Serotypes | DRA | DRB1 | DRB5 |
|---|---|---|---|
| DR16(2)-DR51 | *0101 | *1601 | *0101 |
| *0101 | *1602 | *0101 | |
| *0101 | *1604 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR16(2)-DQ5 (5.2, 1) | *0102 | *0502 | *1601 |
| HLA-A | HLA-B | DRB1 | |
| A2-B51(5)-DR16(2) | *0201 | *5101 | *1601 |
HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.
References
- ↑ derived from IMGT/HLA
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