HLA-DR53
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major histocompatibility complex, class II, DR53
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| Haplotypes | DRA*01:DRB4*0101 DRA*01:DRB4*0102 DRA*01:DRB4*0103 DRA*01:DRB4*0104 | |
| Structure (See HLA-DR) | ||
| Identifiers |
alpha *0101
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| Symbol(s) | HLA-DRA | |
| EBI-HLA | DRA*0101 | |
| Identifiers |
beta 4 *0101 *0102 *0103 *0104
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| Symbol(s) | HLA-DRB4 | |
| EBI-HLA | DRB4*0101 | |
| EBI-HLA | DRB4*0102 | |
| EBI-HLA | DRB4*0103 | |
| EBI-HLA | DRB4*0104 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.[1] and the DRB4 locus presence is linked to HLA-DR7 seropositivity. The DRB4*locus was apparently duplicated from an ancestor of the DRB1-DRB4 common locus around 5 million years ago.[2]
DRB4 locus is only apparent in a small subset of DQ haplotypes, and most individuals lack DRB4. In addition the level of normal expression is 8 fold lower than the DRB1 in cells which can express both.[3] and lowered because of both transcriptional and post-transcriptional regulation.[4]
Alleles
| DRB4* | DR53 | ? | Sample |
| allele | % | % | size (N) |
| 0101 | 95 | 38 | |
| 0103 | 89 | 49 |
DR53 reactive alleles: DRB4*0101, *0103
Unknown reactivity: *0102, *0104 to *0107
Null alleles: *0101102N, *01030102N, *0201N, *0301N
Associated diseases
DRB4*01 is positively associated with Erythema multiforme,[6] Crohn's disease,[7] myasthenia gravis,[8] rheumatoid arthritis[9] Hashimoto's thyroiditis,[10] vitiligo,[11] primary biliary cirrhosis,[12] clozapine-induced agranulocytosis,[13] Vogt-Koyanagi-Harada disease,[14]
HLA-DRB1 linkage
HLA-DR53 serotypes (HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups:
HLA-DR4 - DRB1*04
HLA-DR7 - DRB1*07
HLA-DR9 - DRB1*09
References
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