Homoquinolinic acid

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Homoquinolinic acid
Homoquinolinic acid.svg
Systematic (IUPAC) name
3-(Carboxymethyl)-2-pyridinecarboxylic acid
Identifiers
CAS Number 490-75-5
ATC code None
PubChem CID: 3080554
ChemSpider 2338312
Synonyms Homoquinolinate
Chemical data
Formula C8H7NO4
Molecular mass 181.145 g/mol
  • c1cc(c(nc1)C(=O)O)CC(=O)O
  • InChI=1S/C8H7NO4/c10-6(11)4-5-2-1-3-9-7(5)8(12)13/h1-3H,4H2,(H,10,11)(H,12,13)
  • Key:HQPMJFFEXJELOQ-UHFFFAOYSA-N

Homoquinolinic acid (HQA) is a potent excitotoxin[1] which is a conformationally-restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors.[2][3][4] It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor.[5] HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site.[6]

See also

References

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