Linitis plastica
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| Linitis plastica | |
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| File:Linitis plastica.jpg
Endoscopic image of linitis plastica, where the entire stomach is invaded with stomach cancer, leading to a leather bottle like appearance.
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| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| ICD-10 | C16.9 |
| ICD-9-CM | 151.9 |
| ICD-O | M8142/3 |
| Patient UK | Linitis plastica |
| MeSH | D008039 |
Linitis plastica, also known as Brinton's disease or leather bottle stomach, is a morphological variant of diffuse (or infiltrating) stomach cancer.
Causes of linitis plastica could be lye ingestion or metastatic infiltration of the stomach, particularly breast and lung carcinoma.[1] It is not associated with H. pylori infection or chronic gastritis. The risk factors are undefined, except for rare inherited mutations in E-cadherin, which are found in about 50% of diffuse-type gastric carcinomas.[1]
This cancer (and most other stomach cancers) is more common in Asian countries, particularly Japan.
Presentation
Diffuse stomach cancer is characterized by the presence of poorly differentiated tumor cells. Microscopic appearance is signet ring cell carcinoma, which is tumor cells with mucin droplet that displaces the nucleus to one side.
The appearance of the stomach is like a "leather bottle".[2] It is characterized by a thick, rigid stomach wall caused by diffuse infiltration of tumor cells and extensive fibrosis.
Diarrhea may be a presenting symptom.
Notable cases
Napoleon Bonaparte and many members of his family are thought to have died from this type of cancer, although it is believed by others that he may have died from arsenic poisoning.[3]
References
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Wikimedia Commons has media related to [[commons:Lua error in Module:WikidataIB at line 506: attempt to index field 'wikibase' (a nil value).|Lua error in Module:WikidataIB at line 506: attempt to index field 'wikibase' (a nil value).]]. |
- "Carcinoma of the Stomach." at patient.info
- 67502105 at GPnotebook
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- ↑ 1.0 1.1 Robbins Basic Pathology, 8th Edition
- ↑ "linitis plastica" at Dorland's Medical Dictionary
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
